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OSI Pharmaceuticals Initiates Clinical Development Program For Anti-Diabetes Candidate, PSN821

Published September 5, 2008, 6:17 am, Medical News Today

OSI Pharmaceuticals, Inc. (Nasdaq: OSIP) announced that it has initiated a first-in-human clinical study for its G-protein coupled receptor GPR119 agonist, PSN821, which the Company is developing for the treatment of type 2 diabetes.

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Studying The Accuracy Of DNA Editing In Mammals

Published September 5, 2008, 5:16 am, Medical News Today

Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation.

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Phase Forward Acquires Clarix LLC, Innovation Leader in Web-Integrated Interactive Response Technology (IRT) for ...

Published September 5, 2008, 3:30 am, Business Wire via Yahoo! Finance

WALTHAM, Mass.----Phase Forward , a leading provider of data management solutions for clinical trials and drug safety, today announced that it has acquired privately held Clarix LLC, an innovative provider of fully Web-integrated interactive response technology , for $40 million in cash.

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DNA Editing Tool Flips Its Target

Published September 4, 2008, 7:22 pm, Science Daily

Imagine having to copy an entire book by hand without missing a comma. Our cells face a similar task every time they divide. They must duplicate both their DNA and a subtle pattern of punctuation-like modifications on the DNA known as methylation. Scientists have caught in action one of the tools mammalian cells use to maintain their pattern of methylation. Visualized by X-ray crystallography, ...

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Pathwork Diagnostics Closes $20M Financing

Published September 4, 2008, 6:00 am, PR Newswire via Yahoo! Finance

Pathwork Diagnostics, a molecular diagnostics company focused on oncology, announced the closing today of a $20 million financing led by Abingworth. The announcement came on the heels of FDA's clearance for the Pathwork® Tissue of Origin Test for diagnosis of tumors of uncertain origin, including poorly differentiated, undifferentiated and metastatic tumors.

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DNA editing tool flips its target

Published September 3, 2008, 10:19 am, EurekAlert!

( Emory University ) DNA methylation -- a chemical process cells use to tag genes -- is important for keeping certain genes silent. The structure of the SRA domain of UHRF1, a protein that recognizes DNA that is methylated on only one side of the double helix, gives scientists a glimpse of how methylation is maintained during DNA replication. The SRA domain performs the unusual maneuver of ...

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NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells

Published September 3, 2008, 9:19 am, EurekAlert!

( Worcester Polytechnic Institute ) A team at Worcester Polytechnic Institute has received a three-year, $900,000 award from the National Institutes of Health (one of only 38 awarded through the new EUREKA program) for a project aimed at developing a novel way of transforming adult skin cells into stem-like cells. If successful, the research could result in a relatively simple and ...

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OSI Pharmaceuticals Initiates Clinical Development Program for Anti-Diabetes Candidate, PSN821

Published September 3, 2008, 6:10 am, Centre Daily Times

OSI Pharmaceuticals, Inc. (Nasdaq: OSIP) announced today that it has initiated a first-in-human clinical study for its G-protein coupled receptor GPR119 agonist, PSN821, which the Company is developing for the treatment of type 2 diabetes. Discovered by OSI's diabetes and obesity research team, PSN821 demonstrated both effective glucose lowering and substantial reductions of body weight in ...

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OSI Pharmaceuticals Initiates Clinical Development Program for Anti-Diabetes Candidate, PSN821

Published September 3, 2008, 4:30 am, Business Wire via Yahoo! Finance

MELVILLE, N.Y.----OSI Pharmaceuticals, Inc. announced today that it has initiated a first-in-human clinical study for its G-protein coupled receptor GPR119 agonist, PSN821, which the Company is developing for the treatment of type 2 diabetes.

Full Story


InterMune Earns Development Milestone in HCV Protease Inhibitor Collaboration With Roche

Published September 2, 2008, 5:00 am, PR Newswire via Yahoo! Finance

InterMune, Inc. today announced that InterMune has earned a $15 million development milestone under its development collaboration with Roche for the hepatitis C virus NS3 protease inhibitor compound ITMN-191 , currently in a Phase 1b clinical trial in combination with Pegasys® and Copegus® .

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